Conformational Studies of Poly(β-phenethyl L-aspartate)

A critical analysis of studies assessing L-ornithine-L-aspartate (LOLA) in hepatic encephalopathy treatment.

CONTEXT Experimental and clinical studies suggest that LOLA may have a favorable influence on hepatic encephalopathy due to the effect on the reduction of ammonia, and improvement of the symptoms and laboratory findings. OBJECTIVES To evaluate and to critically analyze the efficacy and/or effectiveness results of the use of LOLA when compared to placebo in the treatment of hepatic encephalopa...

Pharmacological Study on L-ornithine L-aspartate.

塩屋 明利 ・倉石 弘一 ・柿本 守夫 ・玉真 洋子 In a healthy subject, ammonia produced in the body is excreted by the kidney in the form of urea, the product of the urea cycle (1), or converted into substances useful for the body. In cases of hepatic disorders, on the other hand, blood ammonia level is known to increase (2-6). It is likely that ammonia in high concentrations interferes with the TCA cycle (7) and th...

Isothiocyanate and D,L-Sulforaphane on Differential Effects of Phenethyl

Cephalopod vision involves dicarboxylic amino acids: D-aspartate, L-aspartate and L-glutamate.

In the present study, we report the finding of high concentrations of D-Asp (D-aspartate) in the retina of the cephalopods Sepia officinalis, Loligo vulgaris and Octopus vulgaris. D-Asp increases in concentration in the retina and optic lobes as the animal develops. In neonatal S. officinalis, the concentration of D-Asp in the retina is 1.8+/-0.2 micromol/g of tissue, and in the optic lobes it ...

Conformational studies of mitochondrial DNA.

Ring DNA from rat liver mitochondria has been examined by circular dichroism (CD) in the region of the 225 to 320 m/∼ and the followings have been clarified. The ring DNA gives a CD spectral curve somewhat different from linear DNA from nuclei, showing a big positive peak at 266 m/∼ and a small negative band at 243 m!∼. That is, the positive CD band of ring DNA shifted by about 7 m/∼ to the sho...